Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model

PURPOSE: Heat shock protein 90 (HSP90) is essential for the activation and stabilization of numerous oncogenic client proteins. AT13387 is a novel HSP90 inhibitor promoting degradation of oncogenic proteins upon binding, and may also act as a radiosensitizer. For optimal treatment there is, however,...

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Detalles Bibliográficos
Autores principales: Spiegelberg, Diana, Mortensen, Anja C., Selvaraju, Ram K., Eriksson, Olof, Stenerlöw, Bo, Nestor, Marika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819754/
https://www.ncbi.nlm.nih.gov/pubmed/26627081
http://dx.doi.org/10.1007/s00259-015-3260-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819754/
https://www.ncbi.nlm.nih.gov/pubmed/26627081
http://dx.doi.org/10.1007/s00259-015-3260-x

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