TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization

The metalloprotease ADAM10 mediates the shedding of the ectodomain of various cell membrane proteins, including APP, the precursor of the amyloid peptide Aβ, and Notch receptors following ligand binding. ADAM10 associates with the members of an evolutionary conserved subgroup of tetraspanins, referr...

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Detalles Bibliográficos
Autores principales: Jouannet, Stéphanie, Saint-Pol, Julien, Fernandez, Laurent, Nguyen, Viet, Charrin, Stéphanie, Boucheix, Claude, Brou, Christel, Milhiet, Pierre-Emmanuel, Rubinstein, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819958/
https://www.ncbi.nlm.nih.gov/pubmed/26686862
http://dx.doi.org/10.1007/s00018-015-2111-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819958/
https://www.ncbi.nlm.nih.gov/pubmed/26686862
http://dx.doi.org/10.1007/s00018-015-2111-z

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