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The EGFR-HER2 module: a stem cell approach to understanding a prime target and driver of solid tumors

The epidermal growth factor receptor (EGFR) and a co-receptor denoted HER2/ERBB2, are frequently overexpressed or mutated in solid tumors, such as carcinomas and gliomas. In line with driver roles, cancer drugs intercepting EGFR or HER2 currently outnumber therapies targeting other hubs of signal tr...

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Detalles Bibliográficos
Autores principales: Schneider, Marlon R., Yarden, Yosef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820040/
https://www.ncbi.nlm.nih.gov/pubmed/26434585
http://dx.doi.org/10.1038/onc.2015.372