Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis

MDM2, an E3 ubiquitin ligase, is an important negative regulator of tumor suppressor p53. In turn the Mdm2 gene is a transcriptional target of p53, forming a negative feedback loop that is important in cell cycle control. It has recently become apparent that the ubiquitination of p53 by MDM2 can be...

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Detalles Bibliográficos
Autores principales: Kamio, Takuya, Gu, Bai-wei, Olson, Timothy S., Zhang, Yanping, Mason, Philip J., Bessler, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820113/
https://www.ncbi.nlm.nih.gov/pubmed/27042854
http://dx.doi.org/10.1371/journal.pone.0152263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820113/
https://www.ncbi.nlm.nih.gov/pubmed/27042854
http://dx.doi.org/10.1371/journal.pone.0152263

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