Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse

BACE1 is the major drug target for Alzheimer's disease, but we know surprisingly little about its normal function in the CNS. Here, we show that this protease is critically involved in semaphorin 3A (Sema3A)-mediated axonal guidance processes in thalamic and hippocampal neurons. An active membr...

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Detalles Bibliográficos
Autores principales: Barão, Soraia, Gärtner, Annette, Leyva-Díaz, Eduardo, Demyanenko, Galina, Munck, Sebastian, Vanhoutvin, Tine, Zhou, Lujia, Schachner, Melitta, López-Bendito, Guillermina, Maness, Patricia F., De Strooper, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820248/
https://www.ncbi.nlm.nih.gov/pubmed/26299962
http://dx.doi.org/10.1016/j.celrep.2015.07.059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820248/
https://www.ncbi.nlm.nih.gov/pubmed/26299962
http://dx.doi.org/10.1016/j.celrep.2015.07.059

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