Lomustine Nanoparticles Enable Both Bone Marrow Sparing and High Brain Drug Levels – A Strategy for Brain Cancer Treatments

PURPOSE: The blood brain barrier compromises glioblastoma chemotherapy. However high blood concentrations of lipophilic, alkylating drugs result in brain uptake, but cause myelosuppression. We hypothesised that nanoparticles could achieve therapeutic brain concentrations without dose-limiting myelos...

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Detalles Bibliográficos
Autores principales: Fisusi, Funmilola A., Siew, Adeline, Chooi, Kar Wai, Okubanjo, Omotunde, Garrett, Natalie, Lalatsa, Katerina, Serrano, Dolores, Summers, Ian, Moger, Julian, Stapleton, Paul, Satchi-Fainaro, Ronit, Schätzlein, Andreas G, Uchegbu, Ijeoma F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820487/
https://www.ncbi.nlm.nih.gov/pubmed/26903051
http://dx.doi.org/10.1007/s11095-016-1872-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820487/
https://www.ncbi.nlm.nih.gov/pubmed/26903051
http://dx.doi.org/10.1007/s11095-016-1872-x

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