Application of a Plug-and-Play Immunogenicity Assay in Cynomolgus Monkey Serum for ADCs at Early Stages of Drug Development

Immunogenicity assessment during early stages of nonclinical biotherapeutic development is not always warranted. It is rarely predictive for clinical studies and evidence for the presence of anti-drug antibodies (ADAs) may be inferred from the pharmacokinetic (PK) profile. However, collecting and ba...

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Detalles Bibliográficos
Autores principales: Carrasco-Triguero, Montserrat, Davis, Helen, Zhu, Yuda, Coleman, Daniel, Nazzal, Denise, Vu, Paul, Kaur, Surinder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820625/
https://www.ncbi.nlm.nih.gov/pubmed/27092313
http://dx.doi.org/10.1155/2016/2618575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820625/
https://www.ncbi.nlm.nih.gov/pubmed/27092313
http://dx.doi.org/10.1155/2016/2618575

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