Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential

Most human pre-implantation embryos are mosaics of euploid and aneuploid cells. To determine the fate of aneuploid cells and the developmental potential of mosaic embryos, here we generate a mouse model of chromosome mosaicism. By treating embryos with a spindle assembly checkpoint inhibitor during...

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Detalles Bibliográficos
Autores principales: Bolton, Helen, Graham, Sarah J. L., Van der Aa, Niels, Kumar, Parveen, Theunis, Koen, Fernandez Gallardo, Elia, Voet, Thierry, Zernicka-Goetz, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820631/
https://www.ncbi.nlm.nih.gov/pubmed/27021558
http://dx.doi.org/10.1038/ncomms11165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820631/
https://www.ncbi.nlm.nih.gov/pubmed/27021558
http://dx.doi.org/10.1038/ncomms11165

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