Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

Gankyrin is an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. Elevated gankyrin levels are linked to aberrant cellular events including enhanced degradation of tumour suppressor protein p53, and inhibition of gankyrin activity has therefo...

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Detalles Bibliográficos
Autores principales: Chattopadhyay, Anasuya, O’Connor, Cornelius J., Zhang, Fengzhi, Galvagnion, Celine, Galloway, Warren R. J. D., Tan, Yaw Sing, Stokes, Jamie E., Rahman, Taufiq, Verma, Chandra, Spring, David R., Itzhaki, Laura S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820706/
https://www.ncbi.nlm.nih.gov/pubmed/27046077
http://dx.doi.org/10.1038/srep23732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820706/
https://www.ncbi.nlm.nih.gov/pubmed/27046077
http://dx.doi.org/10.1038/srep23732

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