Unfolding mechanism of thrombin-binding aptamer revealed by molecular dynamics simulation and Markov State Model

Thrombin-binding aptamer (TBA) with the sequence 5′GGTTGGTGTGGTTGG3′ could fold into G-quadruplex, which correlates with functionally important genomic regionsis. However, unfolding mechanism involved in the structural stability of G-quadruplex has not been satisfactorily elucidated on experiments s...

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Detalles Bibliográficos
Autores principales: Zeng, Xiaojun, Zhang, Liyun, Xiao, Xiuchan, Jiang, Yuanyuan, Guo, Yanzhi, Yu, Xinyan, Pu, Xuemei, Li, Menglong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820715/
https://www.ncbi.nlm.nih.gov/pubmed/27045335
http://dx.doi.org/10.1038/srep24065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820715/
https://www.ncbi.nlm.nih.gov/pubmed/27045335
http://dx.doi.org/10.1038/srep24065

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