LIG4 mediates Wnt signalling-induced radioresistance

Despite the implication of Wnt signalling in radioresistance, the underlying mechanisms are unknown. Here we find that high Wnt signalling is associated with radioresistance in colorectal cancer (CRC) cells and intestinal stem cells (ISCs). We find that LIG4, a DNA ligase in DNA double-strand break...

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Detalles Bibliográficos
Autores principales: Jun, Sohee, Jung, Youn-Sang, Suh, Han Na, Wang, Wenqi, Kim, Moon Jong, Oh, Young Sun, Lien, Esther M., Shen, Xi, Matsumoto, Yoshihisa, McCrea, Pierre D., Li, Lei, Chen, Junjie, Park, Jae-Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820809/
https://www.ncbi.nlm.nih.gov/pubmed/27009971
http://dx.doi.org/10.1038/ncomms10994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820809/
https://www.ncbi.nlm.nih.gov/pubmed/27009971
http://dx.doi.org/10.1038/ncomms10994

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