Cargando…

LIG4 mediates Wnt signalling-induced radioresistance

Despite the implication of Wnt signalling in radioresistance, the underlying mechanisms are unknown. Here we find that high Wnt signalling is associated with radioresistance in colorectal cancer (CRC) cells and intestinal stem cells (ISCs). We find that LIG4, a DNA ligase in DNA double-strand break...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jun, Sohee, Jung, Youn-Sang, Suh, Han Na, Wang, Wenqi, Kim, Moon Jong, Oh, Young Sun, Lien, Esther M., Shen, Xi, Matsumoto, Yoshihisa, McCrea, Pierre D., Li, Lei, Chen, Junjie, Park, Jae-Il
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820809/ https://www.ncbi.nlm.nih.gov/pubmed/27009971 http://dx.doi.org/10.1038/ncomms10994

Ejemplares similares

Wnt2 complements Wnt/β-catenin signaling in colorectal cancer
por: Jung, Youn-Sang, et al.
Publicado: (2015)

Identification of LIG1 and LIG3 as prognostic biomarkers in breast cancer
por: Sun, Lin, et al.
Publicado: (2021)

PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness
por: Wang, Xin, et al.
Publicado: (2016)

Immunoprotective properties of recombinant LigA and LigB in a hamster model of acute leptospirosis
por: Evangelista, Karen V., et al.
Publicado: (2017)

Degradation of lignin β‐aryl ether units in Arabidopsis thaliana expressing LigD, LigF and LigG from Sphingomonas paucimobilis SYK‐6
por: Mnich, Ewelina, et al.
Publicado: (2016)

The Terminal Immunoglobulin-Like Repeats of LigA and LigB of Leptospira Enhance Their Binding to Gelatin Binding Domain of Fibronectin and Host Cells
por: Lin, Yi-Pin, et al.
Publicado: (2010)

Evaluation of LipL32 and LigA/LigB Knockdown Mutants in Leptospira interrogans Serovar Copenhageni: Impacts to Proteome and Virulence
por: Fernandes, Luis G. V., et al.
Publicado: (2022)

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
por: Jung, Youn-Sang, et al.
Publicado: (2020)

LIG4 Syndrome Associated with Hypocellular Myeloid Dysplasia
por: Tamura, Shinobu, et al.
Publicado: (2018)

Heterologous expression of pathogen-specific genes ligA and ligB in the saprophyte Leptospira biflexa confers enhanced adhesion to cultured cells and fibronectin
por: Figueira, Cláudio Pereira, et al.
Publicado: (2011)

PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis
por: Kim, Moon Jong, et al.
Publicado: (2021)

Fine Mapping of the Interaction between C4b-Binding Protein and Outer Membrane Proteins LigA and LigB of Pathogenic Leptospira interrogans
por: Breda, Leandro C. D., et al.
Publicado: (2015)

Correction: Fine Mapping of the Interaction between C4b-Binding Protein and Outer Membrane Proteins LigA and LigB of Pathogenic Leptospira interrogans
por: Breda, Leandro C. D., et al.
Publicado: (2015)

Divergent roles of the Wnt/PCP Formin Daam1 in renal ciliogenesis
por: Corkins, Mark E., et al.
Publicado: (2019)

LipL41 and LigA/LigB Gene Silencing on a LipL32 Knockout Leptospira interrogans Reveals the Impact of Multiple Mutations on Virulence
por: Fernandes, Luis Guilherme V., et al.
Publicado: (2023)

Lysosomal TMEM9‐LAMTOR4‐controlled mTOR signaling integrity is required for mammary tumorigenesis
por: Zhang, Shengzhe, et al.
Publicado: (2022)

LigDig: a web server for querying ligand–protein interactions
por: Fuller, Jonathan C., et al.
Publicado: (2015)

Dual loss of human POLQ and LIG4 abolishes random integration
por: Saito, Shinta, et al.
Publicado: (2017)

LIG4 syndrome: clinical and molecular characterization in a Chinese cohort
por: Sun, Bijun, et al.
Publicado: (2020)

Identification of Novel Inhibitors of Escherichia coli DNA Ligase (LigA)
por: Alomari, Arqam, et al.
Publicado: (2021)

Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing
por: Blair, Kerry, et al.
Publicado: (2022)

On Strapping the Chest in Phthisis
por: McCrea, John
Publicado: (1874)

Peptide specific monoclonal antibodies of Leptospiral LigA for acute diagnosis of leptospirosis
por: Kanagavel, Murugesan, et al.
Publicado: (2017)

Myopathic mitochondrial DNA depletion syndrome associated with biallelic variants in LIG3
por: Invernizzi, Federica, et al.
Publicado: (2021)

LigAdvisor: a versatile and user-friendly web-platform for drug design
por: Pinzi, Luca, et al.
Publicado: (2021)

The validity of the Ligs digital arthrometer at different loads to evaluate complete ACL ruptures
por: Li, Junqiao, et al.
Publicado: (2023)

Ultra-thin light-weight laser-induced-graphene (LIG) diffractive optics
por: Lee, Younggeun, et al.
Publicado: (2023)

Wnt signaling induces radioresistance through upregulating HMGB1 in esophageal squamous cell carcinoma
por: Zhao, Yuanyuan, et al.
Publicado: (2018)

Wnt3a promotes radioresistance via autophagy in squamous cell carcinoma of the head and neck
por: Jing, Qiancheng, et al.
Publicado: (2019)

Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views
por: Kim, Moon Jong, et al.
Publicado: (2020)

Física relativista
por: McCrea, William Hunter
Publicado: (1965)

Geometría analítica de tres dimensiones
por: McCrea, William Hunter

Cosmology
por: McCrea, William Hunter
Publicado: (1969)

Bipolar disorder and neurophysiologic mechanisms
por: McCrea, Simon M
Publicado: (2008)

The Study of Influenza
por: McCrea, John F.
Publicado: (1962)

Intuition, insight, and the right hemisphere: Emergence of higher sociocognitive functions
por: McCrea, Simon M
Publicado: (2010)

A review and empirical study of the composite scales of the Das–Naglieri cognitive assessment system
por: McCrea, Simon M
Publicado: (2009)

Relativity physics
por: McCrea, William Hunter
Publicado: (1947)

Relativity physics
por: McCrea, William Hunter
Publicado: (1949)

Relativity physics
por: McCrea, William Hunter
Publicado: (1954)

Cannot write session to /tmp/vufind_sessions/sess_t0a65iekc4ukg0aui4vm35s7oa