CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

Target engagement is a critical factor for therapeutic efficacy. Assessment of compound binding to native target proteins in live cells is therefore highly desirable in all stages of drug discovery. We report here the first compound library screen based on biophysical measurements of intracellular t...

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Detalles Bibliográficos
Autores principales: Almqvist, Helena, Axelsson, Hanna, Jafari, Rozbeh, Dan, Chen, Mateus, André, Haraldsson, Martin, Larsson, Andreas, Molina, Daniel Martinez, Artursson, Per, Lundbäck, Thomas, Nordlund, Pär
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820820/
https://www.ncbi.nlm.nih.gov/pubmed/27010513
http://dx.doi.org/10.1038/ncomms11040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820820/
https://www.ncbi.nlm.nih.gov/pubmed/27010513
http://dx.doi.org/10.1038/ncomms11040

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