Cargando…
FoxO1-mediated autophagy is required for NK cell development and innate immunity
Natural killer (NK) cells exert a crucial role in early immune responses as a major innate effector component. However, the underlying mechanisms of NK cell development remain largely elusive. Here we show that robust autophagy appears in the stage of immature NK cells (iNKs), which is required for...
Autores principales: | Wang, Shuo, Xia, Pengyan, Huang, Guanling, Zhu, Pingping, Liu, Jing, Ye, Buqing, Du, Ying, Fan, Zusen |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820827/ https://www.ncbi.nlm.nih.gov/pubmed/27010363 http://dx.doi.org/10.1038/ncomms11023 |
Ejemplares similares
-
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc–dependent manner
por: Xia, Pengyan, et al.
Publicado: (2014) -
RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy
por: Xia, Pengyan, et al.
Publicado: (2014) -
Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2
por: Ye, Buqing, et al.
Publicado: (2017) -
Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation
por: Ye, Buqing, et al.
Publicado: (2014) -
Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice
por: Ye, Buqing, et al.
Publicado: (2018)