Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

Aged haematopoietic stem cells (HSCs) generate more myeloid cells and fewer lymphoid cells compared with young HSCs, contributing to decreased adaptive immunity in aged individuals. However, it is not known how intrinsic changes to HSCs and shifts in the balance between biased HSC subsets each contr...

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Detalles Bibliográficos
Autores principales: Grover, Amit, Sanjuan-Pla, Alejandra, Thongjuea, Supat, Carrelha, Joana, Giustacchini, Alice, Gambardella, Adriana, Macaulay, Iain, Mancini, Elena, Luis, Tiago C., Mead, Adam, Jacobsen, Sten Eirik W., Nerlov, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820843/
https://www.ncbi.nlm.nih.gov/pubmed/27009448
http://dx.doi.org/10.1038/ncomms11075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820843/
https://www.ncbi.nlm.nih.gov/pubmed/27009448
http://dx.doi.org/10.1038/ncomms11075

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