Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering

Sleeping Beauty (SB) is a prominent Tc1/mariner superfamily DNA transposon that provides a popular genome engineering tool in a broad range of organisms. It is mobilized by a transposase enzyme that catalyses DNA cleavage and integration at short specific sequences at the transposon ends. To facilit...

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Detalles Bibliográficos
Autores principales: Voigt, Franka, Wiedemann, Lisa, Zuliani, Cecilia, Querques, Irma, Sebe, Attila, Mátés, Lajos, Izsvák, Zsuzsanna, Ivics, Zoltán, Barabas, Orsolya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820933/
https://www.ncbi.nlm.nih.gov/pubmed/27025571
http://dx.doi.org/10.1038/ncomms11126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820933/
https://www.ncbi.nlm.nih.gov/pubmed/27025571
http://dx.doi.org/10.1038/ncomms11126

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