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Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering

Sleeping Beauty (SB) is a prominent Tc1/mariner superfamily DNA transposon that provides a popular genome engineering tool in a broad range of organisms. It is mobilized by a transposase enzyme that catalyses DNA cleavage and integration at short specific sequences at the transposon ends. To facilit...

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Detalles Bibliográficos
Autores principales:	Voigt, Franka, Wiedemann, Lisa, Zuliani, Cecilia, Querques, Irma, Sebe, Attila, Mátés, Lajos, Izsvák, Zsuzsanna, Ivics, Zoltán, Barabas, Orsolya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820933/ https://www.ncbi.nlm.nih.gov/pubmed/27025571 http://dx.doi.org/10.1038/ncomms11126

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