In vitro and in vivo efficacy of afatinib as a single agent or in combination with gemcitabine for the treatment of nasopharyngeal carcinoma

PURPOSE: Epidermal growth factor receptor (EGFR) is usually overexpressed in nasopharyngeal carcinoma (NPC). We tested the antitumor effects of irreversible ErbB family inhibitor afatinib on human NPC using in vitro and in vivo models. MATERIALS AND METHODS: The effect of afatinib on NPC cells was e...

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Detalles Bibliográficos
Autores principales: Xue, Cong, Tian, Ying, Zhang, Jing, Zhao, Yuanyuan, Zhan, Jianhua, Fang, Wenfeng, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821387/
https://www.ncbi.nlm.nih.gov/pubmed/27099475
http://dx.doi.org/10.2147/DDDT.S94432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821387/
https://www.ncbi.nlm.nih.gov/pubmed/27099475
http://dx.doi.org/10.2147/DDDT.S94432

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