NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG

The KEAP1-NRF2 pathway regulates cellular redox homeostasis by transcriptional induction of genes associated with antioxidant synthesis and detoxification in response to oxidative stress. Previously, we reported that KEAP1 mutation elicits constitutive NRF2 activation and resistance to cisplatin (CD...

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Detalles Bibliográficos
Autores principales: Kasai, Shuya, Arakawa, Nobuyuki, Okubo, Ayaka, Shigeeda, Wataru, Yasuhira, Shinji, Masuda, Tomoyuki, Akasaka, Toshihide, Shibazaki, Masahiko, Maesawa, Chihaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821458/
https://www.ncbi.nlm.nih.gov/pubmed/27045471
http://dx.doi.org/10.1371/journal.pone.0153181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821458/
https://www.ncbi.nlm.nih.gov/pubmed/27045471
http://dx.doi.org/10.1371/journal.pone.0153181

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