Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes

[Image: see text] Isocitrate dehydrogenase is mutated at a key active site arginine residue (Arg172 in IDH2) in many cancers, leading to the synthesis of the oncometabolite (R)-2-hydroxyglutarate (2HG). To investigate the early events following acquisition of this mutation in mammalian cells we crea...

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Detalles Bibliográficos
Autores principales: Walker, Olivia S., Elsässer, Simon J., Mahesh, Mohan, Bachman, Martin, Balasubramanian, Shankar, Chin, Jason W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821487/
https://www.ncbi.nlm.nih.gov/pubmed/26761588
http://dx.doi.org/10.1021/jacs.5b07627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821487/
https://www.ncbi.nlm.nih.gov/pubmed/26761588
http://dx.doi.org/10.1021/jacs.5b07627

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