Genomic Aberrations in Crizotinib Resistant Lung Adenocarcinoma Samples Identified by Transcriptome Sequencing

ALK-break positive non-small cell lung cancer (NSCLC) patients initially respond to crizotinib, but resistance occurs inevitably. In this study we aimed to identify fusion genes in crizotinib resistant tumor samples. Re-biopsies of three patients were subjected to paired-end RNA sequencing to identi...

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Detalles Bibliográficos
Autores principales: Saber, Ali, van der Wekken, Anthonie J., Kok, Klaas, Terpstra, M. Martijn, Bosman, Lisette J., Mastik, Mirjam F., Timens, Wim, Schuuring, Ed, Hiltermann, T. Jeroen N., Groen, Harry J. M., van den Berg, Anke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821611/
https://www.ncbi.nlm.nih.gov/pubmed/27045755
http://dx.doi.org/10.1371/journal.pone.0153065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821611/
https://www.ncbi.nlm.nih.gov/pubmed/27045755
http://dx.doi.org/10.1371/journal.pone.0153065

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