Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation

Hundreds of L1CAM gene mutations have been shown to be associated with congenital hydrocephalus, severe intellectual disability, aphasia, and motor symptoms. How such mutations impair neuronal function, however, remains unclear. Here, we generated human embryonic stem (ES) cells carrying a condition...

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Detalles Bibliográficos
Autores principales: Patzke, Christopher, Acuna, Claudio, Giam, Louise R., Wernig, Marius, Südhof, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821644/
https://www.ncbi.nlm.nih.gov/pubmed/27001749
http://dx.doi.org/10.1084/jem.20150951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821644/
https://www.ncbi.nlm.nih.gov/pubmed/27001749
http://dx.doi.org/10.1084/jem.20150951

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