p53 downregulates the Fanconi anaemia DNA repair pathway

Germline mutations affecting telomere maintenance or DNA repair may, respectively, cause dyskeratosis congenita or Fanconi anaemia, two clinically related bone marrow failure syndromes. Mice expressing p53(Δ31), a mutant p53 lacking the C terminus, model dyskeratosis congenita. Accordingly, the incr...

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Detalles Bibliográficos
Autores principales: Jaber, Sara, Toufektchan, Eléonore, Lejour, Vincent, Bardot, Boris, Toledo, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821997/
https://www.ncbi.nlm.nih.gov/pubmed/27033104
http://dx.doi.org/10.1038/ncomms11091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821997/
https://www.ncbi.nlm.nih.gov/pubmed/27033104
http://dx.doi.org/10.1038/ncomms11091

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