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Conformational heterogeneity of the calmodulin binding interface

Calmodulin (CaM) is a ubiquitous Ca(2+) sensor and a crucial signalling hub in many pathways aberrantly activated in disease. However, the mechanistic basis of its ability to bind diverse signalling molecules including G-protein-coupled receptors, ion channels and kinases remains poorly understood....

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Detalles Bibliográficos
Autores principales: Shukla, Diwakar, Peck, Ariana, Pande, Vijay S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822001/
https://www.ncbi.nlm.nih.gov/pubmed/27040077
http://dx.doi.org/10.1038/ncomms10910