Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition

UHRF1 is an important epigenetic regulator for maintenance DNA methylation. UHRF1 recognizes hemi-methylated DNA (hm-DNA) and trimethylation of histone H3K9 (H3K9me3), but the regulatory mechanism remains unknown. Here we show that UHRF1 adopts a closed conformation, in which a C-terminal region (Sp...

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Detalles Bibliográficos
Autores principales: Fang, Jian, Cheng, Jingdong, Wang, Jiaolong, Zhang, Qiao, Liu, Mengjie, Gong, Rui, Wang, Ping, Zhang, Xiaodan, Feng, Yangyang, Lan, Wenxian, Gong, Zhou, Tang, Chun, Wong, Jiemin, Yang, Huirong, Cao, Chunyang, Xu, Yanhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822050/
https://www.ncbi.nlm.nih.gov/pubmed/27045799
http://dx.doi.org/10.1038/ncomms11197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822050/
https://www.ncbi.nlm.nih.gov/pubmed/27045799
http://dx.doi.org/10.1038/ncomms11197

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