Engineered kinesin motor proteins amenable to small-molecule inhibition

The human genome encodes 45 kinesin motor proteins that drive cell division, cell motility, intracellular trafficking and ciliary function. Determining the cellular function of each kinesin would benefit from specific small-molecule inhibitors. However, screens have yielded only a few specific inhib...

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Detalles Bibliográficos
Autores principales: Engelke, Martin F., Winding, Michael, Yue, Yang, Shastry, Shankar, Teloni, Federico, Reddy, Sanjay, Blasius, T. Lynne, Soppina, Pushpanjali, Hancock, William O., Gelfand, Vladimir I., Verhey, Kristen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822052/
https://www.ncbi.nlm.nih.gov/pubmed/27045608
http://dx.doi.org/10.1038/ncomms11159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822052/
https://www.ncbi.nlm.nih.gov/pubmed/27045608
http://dx.doi.org/10.1038/ncomms11159

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