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Drugging the undruggables: exploring the ubiquitin system for drug development
Dynamic modulation of protein levels is tightly controlled in response to physiological cues. In mammalian cells, much of the protein degradation is carried out by the ubiquitin-proteasome system (UPS). Similar to kinases, components of the ubiquitin system are often dysregulated, leading to a varie...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822129/ https://www.ncbi.nlm.nih.gov/pubmed/27002218 http://dx.doi.org/10.1038/cr.2016.31 |