Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain

The multi-domain enzyme phenylalanine hydroxylase (PAH) catalyzes the hydroxylation of dietary I-phenylalanine (Phe) to I-tyrosine. Inherited mutations that result in PAH enzyme deficiency are the genetic cause of the autosomal recessive disorder phenylketonuria. Phe is the substrate for the PAH act...

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Detalles Bibliográficos
Autores principales: Patel, Dipali, Kopec, Jolanta, Fitzpatrick, Fiona, McCorvie, Thomas J., Yue, Wyatt W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822156/
https://www.ncbi.nlm.nih.gov/pubmed/27049649
http://dx.doi.org/10.1038/srep23748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822156/
https://www.ncbi.nlm.nih.gov/pubmed/27049649
http://dx.doi.org/10.1038/srep23748

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