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Comparative pharmacological characterization of D(1)-like dopamine receptors from Anopheles gambiae, Aedes aegypti and Culex quinquefasciatus suggests pleiotropic signaling in mosquito vector lineages

BACKGROUND: Small molecule antagonists of mosquito dopamine receptors (DARs) are under investigation as a new class of vector-selective insecticides. Antagonists that inhibit the D(1)-like DARs AaDOP2 and CqDOP2 from the mosquitoes Aedes aegypti L. and Culex quinquefasciatus Say, respectively, also...

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Detalles Bibliográficos
Autores principales: Hill, Catherine A., Doyle, Trevor, Nuss, Andrew B., Ejendal, Karin F. K., Meyer, Jason M., Watts, Val J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822259/
https://www.ncbi.nlm.nih.gov/pubmed/27048546
http://dx.doi.org/10.1186/s13071-016-1477-6