4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4(+)CD25(+)FoxP3(+) T Regulatory Cell Suppression

Costimulation with the recombinant SA-4-1BBL agonist of 4-1BB receptor on conventional CD4(+) T cells (Tconvs) overcomes the suppression mediated by naturally occurring CD4(+)CD25(+)FoxP3(+) T regulatory cells (Tregs). The mechanistic basis of this observation has remained largely unknown. Herein we...

Descripción completa

Detalles Bibliográficos
Autores principales: Barsoumian, Hampartsoum B., Yolcu, Esma S., Shirwan, Haval
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822835/
https://www.ncbi.nlm.nih.gov/pubmed/27049955
http://dx.doi.org/10.1371/journal.pone.0153088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822835/
https://www.ncbi.nlm.nih.gov/pubmed/27049955
http://dx.doi.org/10.1371/journal.pone.0153088

Ejemplares similares