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4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4(+)CD25(+)FoxP3(+) T Regulatory Cell Suppression

Costimulation with the recombinant SA-4-1BBL agonist of 4-1BB receptor on conventional CD4(+) T cells (Tconvs) overcomes the suppression mediated by naturally occurring CD4(+)CD25(+)FoxP3(+) T regulatory cells (Tregs). The mechanistic basis of this observation has remained largely unknown. Herein we...

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Detalles Bibliográficos
Autores principales:	Barsoumian, Hampartsoum B., Yolcu, Esma S., Shirwan, Haval
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822835/ https://www.ncbi.nlm.nih.gov/pubmed/27049955 http://dx.doi.org/10.1371/journal.pone.0153088

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