Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

Human genetic studies show that the voltage gated sodium channel 1.7 (Na(v)1.7) is a key molecular determinant of pain sensation. However, defining the Na(v)1.7 contribution to nociceptive signalling has been hampered by a lack of selective inhibitors. Here we report two potent and selective arylsul...

Descripción completa

Detalles Bibliográficos
Autores principales: Alexandrou, Aristos J., Brown, Adam R., Chapman, Mark L., Estacion, Mark, Turner, Jamie, Mis, Malgorzata A., Wilbrey, Anna, Payne, Elizabeth C., Gutteridge, Alex, Cox, Peter J., Doyle, Rachel, Printzenhoff, David, Lin, Zhixin, Marron, Brian E., West, Christopher, Swain, Nigel A., Storer, R. Ian, Stupple, Paul A., Castle, Neil A., Hounshell, James A., Rivara, Mirko, Randall, Andrew, Dib-Hajj, Sulayman D., Krafte, Douglas, Waxman, Stephen G., Patel, Manoj K., Butt, Richard P., Stevens, Edward B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822888/
https://www.ncbi.nlm.nih.gov/pubmed/27050761
http://dx.doi.org/10.1371/journal.pone.0152405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822888/
https://www.ncbi.nlm.nih.gov/pubmed/27050761
http://dx.doi.org/10.1371/journal.pone.0152405

Ejemplares similares