Cargando…

GSK-3α Is a Novel Target of CREB and CREB-GSK-3α Signaling Participates in Cell Viability in Lung Cancer

Overexpression or activation of cyclic AMP-response element-binding protein (CREB) has been known to be involved in several human malignancies, including lung cancer. Genes regulated by CREB have been reported to suppress apoptosis, induce cell proliferation, inflammation, and tumor metastasis. Howe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Sin-Aye, Lee, Jong Woo, Herbst, Roy S., Koo, Ja Seok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822949/ https://www.ncbi.nlm.nih.gov/pubmed/27049759 http://dx.doi.org/10.1371/journal.pone.0153075

Ejemplares similares

Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3β, Neurotrophin-3 and CREB Signaling
por: Hu, Yuan-Shih, et al.
Publicado: (2013)

Empagliflozin Inhibits Hepatic Gluconeogenesis and Increases Glycogen Synthesis by AMPK/CREB/GSK3β Signalling Pathway
por: Yu, Xiaochen, et al.
Publicado: (2022)

Novel Reporter Alleles of GSK-3α and GSK-3β
por: Barrell, William B., et al.
Publicado: (2012)

Structural Plasticity of Dendritic Spines Requires GSK3α and GSK3β
por: Cymerman, Iwona A., et al.
Publicado: (2015)

GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation
por: Gozdz, Agata, et al.
Publicado: (2017)

Imperatorin Positively Regulates Melanogenesis through Signaling Pathways Involving PKA/CREB, ERK, AKT, and GSK3β/β-Catenin
por: Kim, Taejin, et al.
Publicado: (2022)

Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and Thrombosis
por: Moore, Samantha F., et al.
Publicado: (2021)

6-Methylcoumarin Promotes Melanogenesis through the PKA/CREB, MAPK, AKT/PI3K, and GSK3β/β-Catenin Signaling Pathways
por: Kim, Taejin, et al.
Publicado: (2023)

Discrete functions of GSK3α and GSK3β isoforms in prostate tumor growth and micrometastasis
por: Gao, Fei, et al.
Publicado: (2015)

Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection
por: Steele, Lynette, et al.
Publicado: (2021)

Pharmacological evidence for lithium-induced neuroprotection against methamphetamine-induced neurodegeneration via Akt-1/GSK3 and CREB-BDNF signaling pathways
por: Mehrafza, Shafagh, et al.
Publicado: (2019)

PM2.5 induced cardiac hypertrophy via CREB/GSK3b/SOS1 pathway and metabolomics alterations
por: Li, Kuan-Lun, et al.
Publicado: (2018)

PM439. Chronic effects of aripiprazole on the GSK3ß-dependent pathways, NMDA receptor and CREB1 in the rat brain
por: Pan, Bo, et al.
Publicado: (2016)

Fermented Aronia melanocarpa Inhibits Melanogenesis through Dual Mechanisms of the PI3K/AKT/GSK-3β and PKA/CREB Pathways
por: Kim, Da Hee, et al.
Publicado: (2023)

GSK-3–mediated phosphorylation couples ER–Golgi transport and nuclear stabilization of the CREB-H transcription factor to mediate apolipoprotein secretion
por: Barbosa, Sónia, et al.
Publicado: (2017)

Elevation of Hyaluronan Synthase by Magnesium Supplementation Mediated through the Activation of GSK3 and CREB in Human Keratinocyte-Derived HaCaT Cells
por: Marunaka, Kana, et al.
Publicado: (2021)

Chronic administration of aripiprazole activates GSK3β-dependent signalling pathways, and up-regulates GABA(A) receptor expression and CREB1 activity in rats
por: Pan, Bo, et al.
Publicado: (2016)

A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress
por: Lee, Jong Woo, et al.
Publicado: (2015)

Inhibition of GSK3α/β impairs the progression of HNSCC
por: Schulz, Lisa, et al.
Publicado: (2018)

GSK3α: An Important Paralog in Neurodegenerative Disorders and Cancer
por: Silva-García, Octavio, et al.
Publicado: (2020)

Ginseng Total Saponins Reverse Corticosterone-Induced Changes in Depression-Like Behavior and Hippocampal Plasticity-Related Proteins by Interfering with GSK-3β-CREB Signaling Pathway
por: Chen, Lin, et al.
Publicado: (2014)

Selegiline acts as neuroprotective agent against methamphetamine-prompted mood and cognitive related behavior and neurotoxicity in rats: Involvement of CREB/BDNF and Akt/GSK3 signal pathways
por: Feizipour, Saba, et al.
Publicado: (2020)

Analysis of the effect of rutin on GSK-3β and TNF-α expression in lung cancer
por: Wu, Fei, et al.
Publicado: (2017)

Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways
por: Kandezi, Niyoosha, et al.
Publicado: (2020)

Transcriptional profiling of PPARα−/− and CREB3L3−/− livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα
por: Ruppert, Philip M. M., et al.
Publicado: (2019)

CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα
por: Nakagawa, Yoshimi, et al.
Publicado: (2016)

Dynamic range of GSK3α not GSK3β is essential for bidirectional synaptic plasticity at hippocampal CA3-CA1 synapses
por: Shahab, Lion, et al.
Publicado: (2014)

Novel Non-phosphorylated Serine 9/21 GSK3β/α Antibodies: Expanding the Tools for Studying GSK3 Regulation
por: Grabinski, Tessa, et al.
Publicado: (2016)

Enriched Environment Prevents Hypobaric Hypoxia Induced Memory Impairment and Neurodegeneration: Role of BDNF/PI3K/GSK3β Pathway Coupled with CREB Activation
por: Jain, Vishal, et al.
Publicado: (2013)

c-Met and CREB1 are involved in miR-433-mediated inhibition of the epithelial–mesenchymal transition in bladder cancer by regulating Akt/GSK-3β/Snail signaling
por: Xu, X, et al.
Publicado: (2016)

c-Met, CREB1 and EGFR are involved in miR-493-5p inhibition of EMT via AKT/GSK-3β/Snail signaling in prostate cancer
por: Wang, Song, et al.
Publicado: (2017)

Inhibition of AKT/GSK3β/CREB Pathway Improves the Responsiveness to AMPA Receptor Antagonists by Regulating GRIA1 Surface Expression in Chronic Epilepsy Rats
por: Kim, Ji-Eun, et al.
Publicado: (2021)

Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells
por: Oh-hashi, Kentaro, et al.
Publicado: (2021)

Cilostazol disrupts TLR-4, Akt/GSK-3β/CREB, and IL-6/JAK-2/STAT-3/SOCS-3 crosstalk in a rat model of Huntington's disease
por: El-Abhar, Hanan, et al.
Publicado: (2018)

Functions of GSK-3 Signaling in Development of the Nervous System
por: Kim, Woo-Yang, et al.
Publicado: (2011)

The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity
por: Fox, Rebecca M., et al.
Publicado: (2010)

GSK-3α/β and MEK inhibitors assist the microenvironment of tumor initiation
por: Hassan, Ghmkin, et al.
Publicado: (2023)

Fucoidan–Fucoxanthin Ameliorated Cardiac Function via IRS1/GRB2/ SOS1, GSK3β/CREB Pathways and Metabolic Pathways in Senescent Mice
por: Chang, Po-Ming, et al.
Publicado: (2019)

7-Pyrrolidinethoxy-4′-Methoxyisoflavone Prevents Amyloid β–Induced Injury by Regulating Histamine H3 Receptor-Mediated cAMP/CREB and AKT/GSK3β Pathways
por: Wang, Linlin, et al.
Publicado: (2019)

The SIK1/CRTC2/CREB1 and TWIST1/PI3K/Akt/GSK3β signaling pathways mediated by microRNA-25-3p are altered in the schizophrenic rat brain
por: Pan, Bo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_t0775c4r76d2noeii97gcmu34u