Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1

Cardiac aging is characterized by accumulation of damaged proteins and decline of autophagic efficiency. Here, by forestalling SIRT1 carbonylated inactivation in aged heart, we determined the benefits of activation of aldehyde dehydrogenase 2 (ALDH2) on the autophagy. In this study, the ALDH2 KO mic...

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Detalles Bibliográficos
Autores principales: Wu, Bing, Yu, Lu, Wang, Yishi, Wang, Hongtao, Li, Chen, Yin, Yue, Yang, Jingrun, Wang, Zhifa, Zheng, Qiangsun, Ma, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823027/
https://www.ncbi.nlm.nih.gov/pubmed/26741505
http://dx.doi.org/10.18632/oncotarget.6814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823027/
https://www.ncbi.nlm.nih.gov/pubmed/26741505
http://dx.doi.org/10.18632/oncotarget.6814

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