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Polo-like kinase 1 mediates BRCA1 phosphorylation and recruitment at DNA double-strand breaks

Accurate repair of DNA double-strand breaks (DSB) caused during DNA replication and by exogenous stresses is critical for the maintenance of genomic integrity. There is growing evidence that the Polo-like kinase 1 (Plk1) that plays a number of pivotal roles in cell proliferation can directly partici...

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Detalles Bibliográficos
Autores principales: Chabalier-Taste, Corinne, Brichese, Laetitia, Racca, Carine, Canitrot, Yvan, Calsou, Patrick, Larminat, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823034/
https://www.ncbi.nlm.nih.gov/pubmed/26745677
http://dx.doi.org/10.18632/oncotarget.6825