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BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivo
BRCA1 mutation is associated with carcinogenesis, especially of breast tissue. Telomere maintenance is crucial for malignant transformation. Being a part of the DNA repair machinery, BRCA1 may be implicated in telomere biology. We explored the role of BRCA1 in telomere maintenance in lymphocytes of...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823046/ https://www.ncbi.nlm.nih.gov/pubmed/26515461 http://dx.doi.org/10.18632/oncotarget.5693 |