Cargando…

BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivo

BRCA1 mutation is associated with carcinogenesis, especially of breast tissue. Telomere maintenance is crucial for malignant transformation. Being a part of the DNA repair machinery, BRCA1 may be implicated in telomere biology. We explored the role of BRCA1 in telomere maintenance in lymphocytes of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Uziel, Orit, Yerushalmi, Rinat, Zuriano, Lital, Naser, Shaden, Beery, Einat, Nordenberg, Jardena, Lubin, Ido, Adel, Yonatan, Shepshelovich, Daniel, Yavin, Hagai, Aharon, Irit Ben, Pery, Shlomit, Rizel, Shulamit, Pasmanik-Chor, Metsada, Frumkin, Dan, Lahav, Meir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823046/ https://www.ncbi.nlm.nih.gov/pubmed/26515461 http://dx.doi.org/10.18632/oncotarget.5693

Ejemplares similares

The effect of Bortezomib and Rapamycin on Telomerase Activity in Mantle Cell Lymphoma
por: Uziel, Orit, et al.
Publicado: (2014)

Characterisation of blood-derived exosomal hTERT mRNA secretion in cancer patients: a potential pan-cancer marker
por: Goldvaser, Hadar, et al.
Publicado: (2017)

The Effects of Proteasome Inhibitors on Telomerase Activity and Regulation in Multiple Myeloma Cells
por: Shalem-Cohavi, Naama, et al.
Publicado: (2019)

Tumor cells derived exosomes contain hTERT mRNA and transform nonmalignant fibroblasts into telomerase positive cells
por: Gutkin, Anna, et al.
Publicado: (2016)

The Effect of Ethanol on Telomere Dynamics and Regulation in Human Cells
por: Harpaz, Tomer, et al.
Publicado: (2018)

Imatinib mesylate (Gleevec) downregulates telomerase activity and inhibits proliferation in telomerase-expressing cell lines
por: Uziel, O, et al.
Publicado: (2005)

Telomere Shortening Sensitizes Cancer Cells to Selected Cytotoxic Agents: In Vitro and In Vivo Studies and Putative Mechanisms
por: Uziel, Orit, et al.
Publicado: (2010)

Exosomal telomerase transcripts reprogram the microRNA transcriptome profile of fibroblasts and partially contribute to CAF formation
por: Likonen, Daniela, et al.
Publicado: (2022)

Bisphosphonates in the Adjuvant Setting of Breast Cancer Therapy—Effect on Survival: A Systematic Review and Meta-Analysis
por: Ben-Aharon, Irit, et al.
Publicado: (2013)

Correction: Cardiac remodeling secondary to chronic volume overload is attenuated by a novel MMP9/2 blocking antibody
por: Cohen, Lena, et al.
Publicado: (2020)

Proteomic and microRNA data clarifying the effects of telomere shortening on cancer cells
por: Uziel, Orit, et al.
Publicado: (2014)

Differences in Telomere Length between Adolescent Females with Anorexia Nervosa Restricting Type and Anorexia Nervosa Binge-Purge Type
por: Uziel, Orit, et al.
Publicado: (2023)

Doxorubicin-induced ovarian toxicity
por: Ben-Aharon, Irit, et al.
Publicado: (2010)

Hierarchical Partitioning of Metazoan Protein Conservation Profiles Provides New Functional Insights
por: Witztum, Jonathan, et al.
Publicado: (2014)

Simulation and visualization of multiple KEGG pathways using BioNSi
por: Yeheskel, Adva, et al.
Publicado: (2018)

The Association between Treatment for Metabolic Disorders and Breast Cancer Characteristics
por: Goldvaser, Hadar, et al.
Publicado: (2016)

Heterogeneity in the Metastatic Microenvironment: JunB-Expressing Microglia Cells as Potential Drivers of Melanoma Brain Metastasis Progression
por: Adir, Orit, et al.
Publicado: (2023)

De novo transcriptome characterization of Iris atropurpurea (the Royal Iris) and phylogenetic analysis of MADS-box and R2R3-MYB gene families
por: Bar-Lev, Yamit, et al.
Publicado: (2021)

Author Correction: De novo transcriptome characterization of Iris atropurpurea (the Royal Iris) and phylogenetic analysis of MADS-box and R2R3-MYB gene families
por: Bar-Lev, Yamit, et al.
Publicado: (2021)

Differential downregulation of telomerase activity by bortezomib in multiple myeloma cells-multiple regulatory pathways in vitro and ex vivo
por: Weiss, C, et al.
Publicado: (2012)

Effects of IKAP/hELP1 Deficiency on Gene Expression in Differentiating Neuroblastoma Cells: Implications for Familial Dysautonomia
por: Cohen-Kupiec, Rachel, et al.
Publicado: (2011)

HeatMapViewer: interactive display of 2D data in biology
por: Yachdav, Guy, et al.
Publicado: (2014)

Blood-Derived Exosomal hTERT mRNA in Patients with Lung Cancer: Characterization and Correlation with Response to Therapy
por: Rotem, Ofer, et al.
Publicado: (2023)

Systems Analysis of Insulin and IGF1 Receptors Networks in Breast Cancer Cells Identifies Commonalities and Divergences in Expression Patterns
por: Sarfstein, Rive, et al.
Publicado: (2020)

Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage
por: Bigelman, Einat, et al.
Publicado: (2023)

eIF4E and eIF4GI have distinct and differential imprints on multiple myeloma's proteome and signaling
por: Attar-Schneider, Oshrat, et al.
Publicado: (2015)

Genome-Wide Analyses Identify Filamin-A As a Novel Downstream Target for Insulin and IGF1 Action
por: Aizen, Daniel, et al.
Publicado: (2018)

Differential gene expression and transport functionality in the bundle sheath versus mesophyll – a potential role in leaf mineral homeostasis
por: Wigoda, Noa, et al.
Publicado: (2017)

A Tumor Microenvironment-Driven Network Regulated by STAT3 and p65 Negatively Controls the Enrichment of Cancer Stem Cells in Human HR+/HER2− Breast Cancer
por: Ben-Yaakov, Hagar, et al.
Publicado: (2023)

Antiviral activity of glucosylceramide synthase inhibitors in alphavirus infection of the central nervous system
por: Avraham, Roy, et al.
Publicado: (2023)

Peripheral blood telomere alterations in ground glass opacity (GGO) lesions may suggest malignancy
por: Koslow, Matthew, et al.
Publicado: (2019)

Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment
por: Zitman-Gal, Tali, et al.
Publicado: (2014)

Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro
por: Sintov, Elad, et al.
Publicado: (2015)

Intercellular transfer of small RNAs from astrocytes to lung tumor cells induces resistance to chemotherapy
por: Menachem, Assaf, et al.
Publicado: (2016)

Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients
por: Sinai-Livne, Tali, et al.
Publicado: (2020)

The Uncovered Function of the Drosophila GBA1a-Encoded Protein
por: Cabasso, Or, et al.
Publicado: (2021)

MicroRNA 132-3p Is Upregulated in Laron Syndrome Patients and Controls Longevity Gene Expression
por: Yaron-Saminsky, Danielle, et al.
Publicado: (2021)

Serine peptidases and increased amounts of soluble proteins contribute to heat priming of the plant pathogenic fungus Botrytis cinerea
por: Zhang, Mingzhe, et al.
Publicado: (2023)

Inter-Tumor Heterogeneity—Melanomas Respond Differently to GM-CSF-Mediated Activation
por: Moshe, Adi, et al.
Publicado: (2020)

Author Correction: Transcriptome profiling of mouse colonic eosinophils reveals a key role for eosinophils in the induction of s100a8 and s100a9 in mucosal healing
por: Reichman, Hadar, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_4rpbl5lontipip34blco1qgnu8