Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway

The CXCR4 receptor (Chemokine C-X-C motif receptor 4) is highly expressed in different hematological malignancies including chronic lymphocytic leukemia (CLL). The CXCR4 ligand (CXCL12) stimulates CXCR4 promoting cell survival and proliferation, and may contribute to the tropism of leukemia cells to...

Descripción completa

Detalles Bibliográficos
Autores principales: Kashyap, Manoj K., Kumar, Deepak, Jones, Harrison, Amaya-Chanaga, Carlos I., Choi, Michael Y., Melo-Cardenas, Johanna, Ale-Ali, Amine, Kuhne, Michelle R., Sabbatini, Peter, Cohen, Lewis J., Shelat, Suresh G., Rassenti, Laura Z., Kipps, Thomas J., Cardarelli, Pina M., Castro, Januario E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823073/
https://www.ncbi.nlm.nih.gov/pubmed/26646452
http://dx.doi.org/10.18632/oncotarget.6465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823073/
https://www.ncbi.nlm.nih.gov/pubmed/26646452
http://dx.doi.org/10.18632/oncotarget.6465

Ejemplares similares