Obg-like ATPase 1 regulates global protein serine/threonine phosphorylation in cancer cells by suppressing the GSK3β-inhibitor 2-PP1 positive feedback loop

OLA1 is an Obg family P-loop NTPase that possesses both GTP- and ATP-hydrolyzing activities. Here we report that OLA1 is a GSK3β interacting protein, and through its ATPase activity, inhibits the GSK3β-mediated activation of protein serine/threonine phosphatase 1 (PP1). It is hypothesized that GSK3β...

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Detalles Bibliográficos
Autores principales: Xu, Dong, Song, Renduo, Wang, Guohui, Jeyabal, Prince V.S., Weiskoff, Amanda M., Ding, Kefeng, Shi, Zheng-Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823117/
https://www.ncbi.nlm.nih.gov/pubmed/26655089
http://dx.doi.org/10.18632/oncotarget.6496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823117/
https://www.ncbi.nlm.nih.gov/pubmed/26655089
http://dx.doi.org/10.18632/oncotarget.6496

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