Cargando…

Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway

Gamabufotalin (CS-6), a main active compound isolated from Chinese medicine Chansu, has been shown to strongly inhibit cancer cell growth and inflammatory response. However, its effects on angiogenesis have not been known yet. Here, we sought to determine the biological effects of CS-6 on signaling...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Ning, Shi, Lei, Yu, Zhenlong, Dong, Peipei, Wang, Chao, Huo, Xiaokui, Zhang, Baojing, Huang, Shanshan, Deng, Sa, Liu, Kexin, Ma, Tonghui, Wang, Xiaobo, Wu, Lijun, Ma, Xiao-Chi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823125/ https://www.ncbi.nlm.nih.gov/pubmed/26657289 http://dx.doi.org/10.18632/oncotarget.6514

Ejemplares similares

Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells
por: Yu, Zhenlong, et al.
Publicado: (2016)

Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells
por: Yu, Zhenlong, et al.
Publicado: (2014)

Correction: Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells
por: Yu, Zhenlong, et al.
Publicado: (2023)

Quantitative proteomics reveals molecular mechanism of gamabufotalin and its potential inhibition on Hsp90 in lung cancer
por: Zhang, Liyuan, et al.
Publicado: (2016)

Rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression
por: Wang, Min, et al.
Publicado: (2019)

VEGF-dependent tumor angiogenesis requires the inverse and reciprocal regulation of VEGFR1 and VEGFR2
por: Zhang, Zhaocheng, et al.
Publicado: (2009)

Endogenous Bufadienolides, Fibrosis and Preeclampsia
por: Reznik, Vitaliy A., et al.
Publicado: (2019)

DSGOST inhibits tumor growth by blocking VEGF/VEGFR2-activated angiogenesis
por: Choi, Hyeong Sim, et al.
Publicado: (2016)

SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2
por: Choi, Hyeong Sim, et al.
Publicado: (2016)

Coral-Derived Compound WA-25 Inhibits Angiogenesis by Attenuating the VEGF/VEGFR2 Signaling Pathway
por: Lin, Shih-Wei, et al.
Publicado: (2015)

Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
por: Peng, Yulin, et al.
Publicado: (2018)

Sinensetin suppresses angiogenesis in liver cancer by targeting the VEGF/VEGFR2/AKT signaling pathway
por: Li, Xiao, et al.
Publicado: (2022)

Cytotoxic Effects of Arsenite in Combination With Gamabufotalin Against Human Glioblastoma Cell Lines
por: Yuan, Bo, et al.
Publicado: (2021)

Correction: Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
por: Peng, Yulin, et al.
Publicado: (2023)

Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides
por: Shao, Huili, et al.
Publicado: (2021)

OVA66 promotes tumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2 signalling
por: Song, Feifei, et al.
Publicado: (2019)

Geraniol Suppresses Angiogenesis by Downregulating Vascular Endothelial Growth Factor (VEGF)/VEGFR-2 Signaling
por: Wittig, Christine, et al.
Publicado: (2015)

Corrigendum: Cytotoxic Effects of Arsenite in Combination With Gamabufotalin Against Human Glioblastoma Cell Lines
por: Yuan, Bo, et al.
Publicado: (2021)

Bufadienolides originated from toad source and their anti-inflammatory activity
por: Zou, Denglang, et al.
Publicado: (2022)

VEGF-VEGFR Signals in Health and Disease
por: Shibuya, Masabumi
Publicado: (2014)

Regulation of Pathologic Retinal Angiogenesis in Mice and Inhibition of VEGF-VEGFR2 Binding by Soluble Heparan Sulfate
por: Nishiguchi, Koji M., et al.
Publicado: (2010)

Inhibition of VEGF(165)/VEGFR2-dependent signaling by LECT2 suppresses hepatocellular carcinoma angiogenesis
por: Chen, Chi-Kuan, et al.
Publicado: (2016)

SAIF plays anti-angiogenesis via blocking VEGF-VEGFR2-ERK signal in tumor treatment
por: Xie, Junye, et al.
Publicado: (2023)

Gambogic amide inhibits angiogenesis by suppressing VEGF/VEGFR2 in endothelial cells in a TrkA-independent manner
por: Sui, Tongtong, et al.
Publicado: (2021)

Molecular Structure-Affinity Relationship of Bufadienolides and Human Serum Albumin In Vitro and Molecular Docking Analysis
por: Zhou, Jing, et al.
Publicado: (2015)

Changes in the Expression Profile of VEGF-A, VEGF-B, VEGFR-1, VEGFR-2 in Different Grades of Endometrial Cancer
por: Dziobek, Konrad, et al.
Publicado: (2019)

A peptide mimicking the binding sites of VEGF-A and VEGF-B inhibits VEGFR-1/-2 driven angiogenesis, tumor growth and metastasis
por: Farzaneh Behelgardi, Maryam, et al.
Publicado: (2018)

New Bufadienolides Isolated from the Roots of Kalanchoe daigremontiana (Crassulaceae)
por: Moniuszko-Szajwaj, Barbara, et al.
Publicado: (2016)

Anti-gastric cancer activity in three-dimensional tumor spheroids of bufadienolides
por: Wang, Jixia, et al.
Publicado: (2016)

Calbindin S100A16 Promotes Renal Cell Carcinoma Progression and Angiogenesis via the VEGF/VEGFR2 Signaling Pathway
por: Wang, Ning, et al.
Publicado: (2022)

Targeting VEGF/VEGFR to Modulate Antitumor Immunity
por: Yang, Ju, et al.
Publicado: (2018)

Diagnostic Value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline Mammary Carcinoma
por: Nascimento, Catarina, et al.
Publicado: (2021)

Visfatin promotes angiogenesis of RF/6A cells through upregulation of VEGF/VEGFR-2 under high-glucose conditions
por: Chen, Dongjun, et al.
Publicado: (2021)

Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-derived VEGF in tumor model through modulating VEGF-VEGFR2 signaling pathway
por: Fu, Zhongping, et al.
Publicado: (2015)

Novel Nargenicin A1 Analog Inhibits Angiogenesis by Downregulating the Endothelial VEGF/VEGFR2 Signaling and Tumoral HIF-1α/VEGF Pathway
por: Han, Jang Mi, et al.
Publicado: (2020)

Cytotoxicity of VEGF(121)/rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2
por: Mohamedali, Khalid A, et al.
Publicado: (2011)

Syntenin promotes VEGF-induced VEGFR2 endocytosis and angiogenesis by increasing ephrin-B2 function in endothelial cells
por: Tae, Nara, et al.
Publicado: (2017)

The Potential Mechanism of Bufadienolide-Like Chemicals on Breast Cancer via Bioinformatics Analysis
por: Zhang, Yingbo, et al.
Publicado: (2019)

Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling
por: Zhou, Xunian, et al.
Publicado: (2016)

Rutacecarpine Inhibits Angiogenesis by Targeting the VEGFR2 and VEGFR2-Mediated Akt/mTOR/p70s6k Signaling Pathway
por: Ji, Lijun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ik05qfut4cigj6idlt2t4j5g6f