MHC class I protects motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis (ALS)

Astrocytes isolated from individuals with amyotrophic lateral sclerosis (ALS) are toxic towards motor neurons (MNs) and play a non-cell autonomous role in disease pathogenesis. The mechanisms underlying the susceptibility of motor neurons to cell death remains unclear. Here, we report that astrocyte...

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Detalles Bibliográficos
Autores principales: Song, SungWon, Miranda, Carlos J., Braun, Lyndsey, Meyer, Kathrin, Frakes, Ashley E., Ferraiuolo, Laura, Likhite, Shibi, Bevan, Adam K., Foust, Kevin D., McConnell, Michael J., Walker, Christopher M., Kaspar, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823173/
https://www.ncbi.nlm.nih.gov/pubmed/26928464
http://dx.doi.org/10.1038/nm.4052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823173/
https://www.ncbi.nlm.nih.gov/pubmed/26928464
http://dx.doi.org/10.1038/nm.4052

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