Characterisation of an epigenetically altered CD4(+) CD28(+) Kir(+) T cell subset in autoimmune rheumatic diseases by multiparameter flow cytometry

OBJECTIVES: Antigen-specific CD4(+) T cells epigenetically modified with DNA methylation inhibitors overexpress genes normally suppressed by this mechanism, including CD11a, CD70, CD40L and the KIR gene family. The altered cells become autoreactive, losing restriction for nominal antigen and respond...

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Detalles Bibliográficos
Autores principales: Strickland, Faith M, Patel, Dipak, Khanna, Dinesh, Somers, Emily, Robida, Aaron M, Pihalja, Michael, Swartz, Richard, Marder, Wendy, Richardson, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Biomarker Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823547/
https://www.ncbi.nlm.nih.gov/pubmed/27099767
http://dx.doi.org/10.1136/lupus-2016-000147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823547/
https://www.ncbi.nlm.nih.gov/pubmed/27099767
http://dx.doi.org/10.1136/lupus-2016-000147

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