RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of Aβ oligomers

Bexarotene, a selective agonist for Retinoid X receptors (RXR) improves cognitive deficits and amyloid-β (Aβ) clearance in mice. Here we examine if the effect of bexarotene on RXR cistrome and transcriptomes depend on APOE isoform and Aβ deposition. We found bexarotene increased RXR binding to promo...

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Detalles Bibliográficos
Autores principales: Nam, Kyong Nyon, Mounier, Anais, Fitz, Nicholas F., Wolfe, Cody, Schug, Jonathan, Lefterov, Iliya, Koldamova, Radosveta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823697/
https://www.ncbi.nlm.nih.gov/pubmed/27051978
http://dx.doi.org/10.1038/srep24048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823697/
https://www.ncbi.nlm.nih.gov/pubmed/27051978
http://dx.doi.org/10.1038/srep24048

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