Novel mechanism of enhancing IRE1α-XBP1 signalling via the PERK-ATF4 pathway

Mammalian inositol-requiring enzyme 1α (IRE1α) is the most conserved of all endoplasmic reticulum (ER) stress sensors, which includes activating transcription factor (ATF) 6 and double-stranded RNA-dependent protein kinase (PKR)-like ER kinase (PERK). IRE1α has been known to splice X-box binding pro...

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Detalles Bibliográficos
Autores principales: Tsuru, Akio, Imai, Yasutaka, Saito, Michiko, Kohno, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823713/
https://www.ncbi.nlm.nih.gov/pubmed/27052593
http://dx.doi.org/10.1038/srep24217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823713/
https://www.ncbi.nlm.nih.gov/pubmed/27052593
http://dx.doi.org/10.1038/srep24217

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