PGC-1α Promotes Ureagenesis in Mouse Periportal Hepatocytes through SIRT3 and SIRT5 in Response to Glucagon

Excess ammonia is produced during fasting when amino acids are used for glucogenesis. Together with ureagenesis, glucogenesis occurs in periportal hepatocytes mediated mainly through the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). In vivo experiments showed that fa...

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Detalles Bibliográficos
Autores principales: Li, Lulu, Zhang, Ping, Bao, Zhengxi, Wang, Tongxin, Liu, Shuang, Huang, Feiruo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823758/
https://www.ncbi.nlm.nih.gov/pubmed/27052737
http://dx.doi.org/10.1038/srep24156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823758/
https://www.ncbi.nlm.nih.gov/pubmed/27052737
http://dx.doi.org/10.1038/srep24156

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