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B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus

BACKGROUND: Neuropsychiatric lupus (NPSLE) can be one of the earliest clinical manifestations in human lupus. However, its mechanisms are not fully understood. In lupus, a compromised blood-brain barrier may allow for the passage of circulating autoantibodies into the brain, where they can induce ne...

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Detalles Bibliográficos
Autores principales: Wen, Jing, Doerner, Jessica, Chalmers, Samantha, Stock, Ariel, Wang, Haowei, Gullinello, Maria, Shlomchik, Mark J., Putterman, Chaim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823887/
https://www.ncbi.nlm.nih.gov/pubmed/27055816
http://dx.doi.org/10.1186/s12974-016-0537-3