Overcoming MITF-conferred drug resistance through dual AURKA/MAPK targeting in human melanoma cells

MITF (microphthalmia-associated transcription factor) is a frequently amplified lineage-specific oncogene in human melanoma, whose role in intrinsic drug resistance has not been systematically investigated. Utilizing chemical inhibitors for major signaling pathways/cellular processes, we witness MIT...

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Detalles Bibliográficos
Autores principales: Pathria, G, Garg, B, Borgdorff, V, Garg, K, Wagner, C, Superti-Furga, G, Wagner, S N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823922/
https://www.ncbi.nlm.nih.gov/pubmed/26962685
http://dx.doi.org/10.1038/cddis.2015.369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823922/
https://www.ncbi.nlm.nih.gov/pubmed/26962685
http://dx.doi.org/10.1038/cddis.2015.369

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