Necroptosis in Niemann–Pick disease, type C1: a potential therapeutic target

Niemann–Pick disease, type C1 (NPC1) is a neurodegenerative, lysosomal storage disorder due to mutation of the NPC1 gene. The NPC1 phenotype is characterized by progressive neuronal dysfunction, including cerebellar ataxia and dementia. There is histological evidence of neuroinflammation and progres...

Descripción completa

Detalles Bibliográficos
Autores principales: Cougnoux, A, Cluzeau, C, Mitra, S, Li, R, Williams, I, Burkert, K, Xu, X, Wassif, C A, Zheng, W, Porter, F D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823930/
https://www.ncbi.nlm.nih.gov/pubmed/26986514
http://dx.doi.org/10.1038/cddis.2016.16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823930/
https://www.ncbi.nlm.nih.gov/pubmed/26986514
http://dx.doi.org/10.1038/cddis.2016.16

Ejemplares similares