Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation

Evidence implicates ARTD1 in cell differentiation, but its role in skeletal metabolism remains unknown. Osteoclasts (OC), the bone-resorbing cells, differentiate from macrophages under the influence of macrophage colony-stimulating factor (M-CSF) and receptor-activator of NF-κB ligand (RANKL). We fo...

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Detalles Bibliográficos
Autores principales: Wang, C, Qu, C, Alippe, Y, Bonar, S L, Civitelli, R, Abu-Amer, Y, Hottiger, M O, Mbalaviele, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823959/
https://www.ncbi.nlm.nih.gov/pubmed/27010854
http://dx.doi.org/10.1038/cddis.2016.58

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823959/
https://www.ncbi.nlm.nih.gov/pubmed/27010854
http://dx.doi.org/10.1038/cddis.2016.58

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