Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson's disease

The co-enzyme nicotinamide adenine dinucleotide (NAD(+)) is an essential co-factor for cellular energy generation in mitochondria as well as for DNA repair mechanisms in the cell nucleus involving NAD(+)-consuming poly (ADP-ribose) polymerases (PARPs). Mitochondrial function is compromised in animal...

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Detalles Bibliográficos
Autores principales: Lehmann, S, Costa, A C, Celardo, I, Loh, S H Y, Martins, L M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823968/
https://www.ncbi.nlm.nih.gov/pubmed/27031963
http://dx.doi.org/10.1038/cddis.2016.72

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823968/
https://www.ncbi.nlm.nih.gov/pubmed/27031963
http://dx.doi.org/10.1038/cddis.2016.72

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